Coagulation Reagents

Our Coagulation Reagent portfolio offers:

• Flexibility of vial sizes
• Provides superb on-board stability across our Sysmex coagulation analysers
• Acquisition of HYPHEN Biomed enables us to provide a comprehensive line of reagents to complement our existing Siemens haemostasis reagents portfolio.
• Enables to provide our customers with innovative technologies and the highest quality performance from our Sysmex coagulation analysers.

1. Dade Innovin

• Prepared from purified recombinant human tissue factor produced in E. coli, combined with synthetic phospholipids, calcium, buffers, and stabilisers.
• Highly sensitive to extrinsic factor deficiencies and oral anticoagulant-treated patient plasma samples.
• Sensitivity very similar to that of the WHO human brain reference thromboplastin.
• Insensitive to therapeutic levels of heparin, which, in combination with high sensitivity to coagulation factors, makes Dade Innovin Reagent ideal for monitoring oral anticoagulant therapy and differentiating abnormal plasmas, even in the mildly pathological range.

2. Thromborel S

• Prepared from human placental tissue factor combined with calcium chloride and stabilisers.
• Contains minimal residual clotting factors, such as prothrombin or factors VII or X, for clear definition of factor deficiencies and steep factor assay curves.
• Because of its high sensitivity to these coagulation factors, the reagent is suitable for monitoring oral anticoagulant therapy.
• Exhibits good correlation with the WHO international reference thromboplastin preparation.
• With the Thromborel S Reagent and the appropriate deficient plasma, it is possible to determine activity of coagulation factors II, V, VII, and X.
• Differentiates abnormal plasmas, even in the mildly pathological range.

1. Dade Actin Reagent

• Moderate sensitivity to factor deficiencies (VIII, IX, XI, and XII) in the intrinsic system.
• Ideal choice for institutions requiring a moderate screening APTT reagent for routine testing.
• Dade Actin Activated Cephaloplastin Reagent has low heparin sensitivity, allowing the monitoring of heparin therapy even with high heparin dosage.
• It has moderate sensitivity to lupus anticoagulants.

2. Dade Actin FS Reagent

• Highly sensitive reagent for the detection of factor deficiencies (VIII, IX, XI and XII) of the intrinsic system. With moderate sensitivity to lupus anticoagulants and high sensitivity to heparin, it fulfils all requirements of routine coagulation testing.

3. Dade Actin FSL Reagent

• Exhibits increased sensitivity to lupus anticoagulants and moderate heparin sensitivity.
• Good factor sensitivity to detect clinically significant deficiencies of the intrinsic system.

4. Pathromtin SL

• Exhibits high sensitivity to lupus anticoagulants, factor deficiencies, and heparin.

1. Dade Thrombin

• Effective reagent for use in the determination (Clauss method) of fibrinogen in the detection of hereditary or acquired hypo- and hyper fibrinogenaemia, dysfibrinogenemia, and afibrinogenemia.
• Offers long stability after reconstitution.

2. Dade Firbrinogen Determination Reagents

• Consists of Dade Thrombin Reagent, Fibrinogen Standard, and Dade Owren’s Veronal Buffer
• Use in the determination of fibrinogen (Clauss method) in the detection of hereditary or acquired hypo- and hyperfibrinogenemia, dysfibrinogenemia, and afibrinogenemia.
• Offers long stability after reconstitution.

3. Multifibren U Reagent

• Bbovine thrombin reagent used in the modified Clauss determination of fibrinogen for the detection of hereditary or acquired hypo-and hyperfibrinogenemia and dysfibrinogenemia.
• Insensitive to heparin up to 2.0 U/mL and has a wide measuring range of 0.80–12.00 g/L.

1. Test Thrombin Reagent

• Intended for the determination of thrombin time in citrated human plasma.
• Suitable for monitoring of fibrinolytic therapy
• Screening for disorders of fibrin formation
• In suspected cases of severe fibrinogen deficiency states
• Differentiation between heparin-induced prolongation of thrombin time and disorders of fibrinogen formation.

2. Thromboclotin Reagent

• Intended for the determination of thrombin time in citrated human plasma.
• Suitable for monitoring of fibrinolytic therapy
• Screening for disorders of fibrin formation
• Suspected cases of severe fibrinogen deficiency states
• Differentiation between heparin-induced prolongation of the thrombin time and disorders of fibrinogen formation.

1. DEFICIENT FACTOR

• Factor II Deficient Plasma
• Factor V Deficient Plasma
• Factor VII Deficient Plasma
• Factor VIII Deficient Plasma
• Factor IX Deficient Plasma
• Factor X Deficient Plasma
• Factor XI Deficient Plasma
• Factor XII Deficient Plasma
• Berichrom Factor VIII Chromogenic
• Berichrom Factor XIII Chromogenic

• LA1 SCREENING
• LA2 CONFIRMATION

• D DIMER
• FDP

• PROTEIN C
• ANTI THROMBIN

• VON WILLEBRAND FACTOR